Publications


Selected publications (for an updated publication list please visit the website of each research partner).

Hoeijmakers JH (2009). DNA Damage, aging, and cancer, NEJM 361, 1475-1485

Garinis GA et al (2008). DNA damage & ageing: new-age ideas for an age-old problem. Nature Cell Biol. 10, 1241-1247

Niedernhofer LJ et al (2006). A new progeriod syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 444, 1038-1043

Jasencakova, Z et al. (2010). Replication stress interferes with histone recycling and predeposition marking of new histones. Mol Cell 37, 736-743.

Jasencakova, Z et al. (2010b). Restoring chromatin after replication: how new and old histone marks come together. Semin Cell Dev Biol 21, 231-237.

Groth, A et al. (2007). Regulation of replication fork progression through histone supply and demand. Science 318, 1928-1931.

Ahel, D., et al (2010). Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science, 325(5945): p. 1240-3.

Youds, M et al. (2010). RTEL-1 enforces meiotic crossover interference and homeostasis. Science, (327): p. 1254-1258.

Barber, L.J et al. (2008). RTEL1 maintains genomic stability by suppressing homologous recombination. Cell, 135(2): p. 261-71.

Garinis GA et al (2009). Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nature Cell Biol 11(5): 604-615

Schumacher B et al (2008). Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet 4(8): e1000161

Schumacher B et al (2005). Translational repression of C. elegans p53 by GLD1 regulates DNA damage-induced apoptosis. Cell 120(3): 357-368

Nagy Z et al (2009). DNA repair: easy to visualize, difficult to elucidate. Trends Cell Biol 19, 617-629.

Soutoglou, E et al. (2008). Activation of the cellular DNA damage response in the absence of DNA lesions. Science 320, 1507-1510.

Soutoglou E et al (2007). Positional stability of single double-strand breaks in mammalian cells. Nature Cell Biol 9, 675-682.

Robert T et al (2011). Class I and II deacetylases influence the DNA damage response and link double strand break processing with autophagy. Nature (in press).

Doksani Y et al (2009).Replicon dynamics, dormant origin firing, and terminal fork integrity after double-strand break formation. Cell 17:247-58

Bermejo R et al (2009). Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription. Cell;138: 870-84.

Lopez-Contreras et al (2010). The ATR barrier to replication-born DNA damage. DNA Repair 9, 1249-1255.

Murga, M. et al (2009). A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet 41, 891-898.

Toledo LI et al (2008). ATR signaling can drive cells into senescence in the absence of DNA breaks. Genes Dev 22, 297-302.

Duro E et al (2010). Identification of the MMS22L–TONSL complex that promotes homologous recombination. Mol Cell 40, 632-644.

MacKay C et al (2010). Identification of KIAA1018/FAN1, a DNA repair endonuclease recruited to DNA damage by mono-ubiquitinated FANCD2. Cell 142, 65-76.

Munoz IM et al (2009). Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Mol Cell 35, 116-127.

Tzima S et al (2009). Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med 206, 1167.

Ermolaeva MA et al (2008). Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses.Nat Immunol 9, 1037.

Gareus R et al (2008). Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. Cell Metab 8, 372.

Tzima S et al (2009). Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production. J Exp Med 206, 1167.

Ermolaeva MA et al (2008). Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses.Nat Immunol 9, 1037.

Gareus R et al (2008). Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. Cell Metab 8, 372.

Kalay E et al (2011). CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Nat Genet 43(1): 23-26

Rutsch F et al (2009). Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism. Nat Genet 41(2): 234-239

Seelow D et al (2009). HomozygosityMapper--an interactive approach to homozygosity mapping. Nucleic Acids Res 37: W593-599

 

 
aDDRess is a Marie Curie Initial Training Network funded by the European Commission 7th Framework Programme, Grant Agreement no.: 316390